With just under seven minutes to play in the third quarter and Golden State trailing 73-56, Durant dribbled up court and attempted to blow by Westbrook, who knocked the ball out-of-bounds.
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Following the play, the two exchanged words and ended up face-to-face before teammates and an official broke up the discussion.
The pair also appeared to jaw with one another late in the second quarter.
Durant addressed the confrontation with reporters after the game.
Oklahoma City came away with a 108-91 victory over the Warriors. Durant spent nine seasons with the Thunder franchise before signing with Golden State prior to 2016-17. Westbrook and Durant were involved in a similar incident last season in mid-February.