The defender has torn a muscle in his right thigh in a continuation of his frustrating start to life in Turin.
On loan from Schalke, the 29-year-old has appeared only once in Serie A as he battles persistent injuries.
Howedes missed Friday’s crucial 1-0 win at leaders Napoli, which saw Juve close the gap at the top to a single point.
The Bianconeri now turn their attention to sealing a place in the Champions League knockout stages, which they can do with a win away to Olympiakos on Tuesday.
Croatia forward Mario Mandzukic is a doubt for the trip to Athens after picking up a calf problem in training.
